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In distinction, omalizumab-mediated inhibition of CD23 binding to IgE is effected by both equally significant steric overlap concerning omalizumab and CD23, and through direct Competitiveness for IgE-binding residues by the omalizumab major chain41. Comparisons on the omalizumab and ligelizumab complexes with IgE (Fig. 1j–o and Supplementary Fig. 4) exhibit the antibody binding footprints and orientations add to the significant dissimilarities in their relative qualities to inhibit CD23 or FcεRIα binding.
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